[甲钴胺对机械性和毒素性去神经支配后神经肌肉功能恢复的作用机制]
[Mechanism of the effect of methylcobalamin on the recovery of neuromuscular functions in mechanical and toxin denervation].
作者信息
Mikhaĭlov V V, Mikhaĭlov V V, Avakumov V M
出版信息
Farmakol Toksikol. 1983 Nov-Dec;46(6):9-12.
PMID:6653768
Abstract
It has been shown in experiments on rats that daily administration of methylcobalamine in a dose of 50 micrograms/100 g bw produces marked activation of the regeneration of mechanically damaged axons of motoneurons. Systematic administration of the drug has a protective action on the development of neuromuscular transmission blockade induced by botulinum toxoid.
摘要
在大鼠实验中已表明，每日以50微克/100克体重的剂量给予甲钴胺，可显著激活运动神经元机械损伤轴突的再生。该药物的系统性给药对肉毒类毒素诱导的神经肌肉传递阻滞的发展具有保护作用。
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