蓖麻毒素B链可将无细胞毒性的抗体-蓖麻毒素A链偶联物转化为一种强效且特异的细胞毒性剂。
Ricin B chain converts a non-cytotoxic antibody-ricin A chain conjugate into a potent and specific cytotoxic agent.
作者信息
McIntosh D P, Edwards D C, Cumber A J, Parnell G D, Dean C J, Ross W C, Forrester J A
出版信息
FEBS Lett. 1983 Nov 28;164(1):17-20. doi: 10.1016/0014-5793(83)80009-x.
PMID:6653781
Abstract
We report the conversion of a non-cytotoxic antibody-ricin A chain conjugate to one displaying specific cytotoxic effects comparable with that of native ricin, by the addition of ricin B chain as a second stage reagent. The results suggest that this conversion is achieved by the association of the added B chain with the A chain of the conjugate, and not through a primary binding of B chain at the cell surface.
摘要
我们报告了通过添加蓖麻毒素B链作为第二阶段试剂，将无细胞毒性的抗体 - 蓖麻毒素A链缀合物转化为具有与天然蓖麻毒素相当的特异性细胞毒性作用的缀合物。结果表明，这种转化是通过添加的B链与缀合物的A链结合实现的，而不是通过B链在细胞表面的初次结合。
Zotero 插件