[1-脱氨基青霉胺，8-α-羟基异己酸]缩宫素。大鼠子宫对缩宫素反应的选择性抑制剂。
[1-Desaminopenicillamine, 8-alpha-hydroxyisocaproic acid] oxytocin. A selective inhibitor in rats of the uterine response to oxytocin.
作者信息
Gazis D, Roy U, Schwartz I L, Roy J
出版信息
Int J Pept Protein Res. 1983 Oct;22(4):450-5. doi: 10.1111/j.1399-3011.1983.tb02114.x.
Abstract
[1-Desaminopenicillamine, 8-alpha-hydroxyisocaproic acid] oxytocin was synthesized by a 6 + 3 fragment condensation from precursors which had been formed by solution methods. This analog inhibited uterine responses to oxytocin (pA2 7.37, 7.9, 6.17; uterus in vitro without Mg++, in vitro with Mg++, and in vivo, respectively) and showed little or no activity in other bioassays.
摘要
[1-脱氨基青霉胺，8-α-羟基异己酸]缩宫素通过溶液法形成的前体经6 + 3片段缩合合成。该类似物抑制子宫对缩宫素的反应（pA2分别为7.37、7.9、6.17；分别为无镁离子的体外子宫、有镁离子的体外子宫和体内子宫），且在其他生物测定中显示出很少或没有活性。
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