Inhibition of gastric acid secretion in conscious dog with fistula following intragastric administration of FPL 52694.

The effects of a mast cell stabilizing agent, FPL 52694, on gastric acid secretion have been investigated in conscious dogs with gastric fistulae. This drug, given by intragastric instillation, inhibited acid output in response to submaximal infusions of pentagastrin and of histamine. A prolonged and significant fall in the acid concentration of the gastric juice was also observed. In the same animals, secretory inhibition by cimetidine was not accompanied by a sustained fall in acid concentration. The inhibition of histamine-induced secretion makes it unlikely that these effects of FPL 52694 are due to prevention of endogenous histamine release.