Khodadoust A A, Stark W J, Bell W R
Invest Ophthalmol Vis Sci. 1983 Dec;24(12):1616-9.
Clinical observations indicated a prompt cessation of episcleral capillary bleeding after exposure of those tissues to aqueous humor during intraocular surgery. Based on this observation, both aqueous and vitreous humors were obtained from eyes provided by an eye bank and from human eyes prior to intraocular surgery. Samples of cerebrospinal fluid also were obtained from two patients, one with optic atrophy and another with nutritional amblyopia. A total of 49 specimens were studied. Aqueous humor shortened the average ear lobe puncture bleeding time from 4.74 +/- 0.2 to 1.13 +/- 0.1 minutes. Varying dilutions of aqueous humor, up to a dilution of 1:16, shortened prothrombin and partial thromboplastin times when compared with normal control plasma without aqueous. Vitreous humor shortened partial thromboplastin time but had no effect on prothrombin time. The effect of cerebrospinal fluid on prothrombin and partial thromboplastin times was similar to the aqueous, but to a lesser degree.
临床观察表明，在眼内手术期间将巩膜上组织暴露于房水后，巩膜上毛细血管出血迅速停止。基于这一观察结果，从眼库提供的眼睛以及眼内手术前的人眼中获取了房水和玻璃体。还从两名患者身上获取了脑脊液样本，一名患有视神经萎缩，另一名患有营养性弱视。总共研究了49个标本。房水使耳垂穿刺平均出血时间从4.74±0.2分钟缩短至1.13±0.1分钟。与不含房水的正常对照血浆相比，高达1:16稀释度的不同稀释度房水缩短了凝血酶原时间和部分凝血活酶时间。玻璃体缩短了部分凝血活酶时间，但对凝血酶原时间没有影响。脑脊液对凝血酶原时间和部分凝血活酶时间的影响与房水相似，但程度较小。
