Viard P, Magne J L, Bouchet C, Fargnoli J M, Carpentier P, Franco A, Peyrin J C, Guidicelli H
J Chir (Paris). 1983 Nov;120(11):643-6.
Five patients with humoral intolerance to heparin developed acute thromboses, with a fatal outcome in two cases from failure to establish the diagnosis, marked sequelae in one case, and recovery without complications in the other two. Accidents of this type may occur in 0.6 p. cent of patients on heparin therapy and are almost always fatal if administration is not discontinued. They result from a severe immunoallergic. Thrombocytopenia which may lead to the formation of arterial clots. Arterial thrombosis during heparin therapy is suggestive of the diagnosis and tests for diminished platelet counts are necessary. Apart from surgery, treatment involves the immediate cessation of heparin therapy.
五名对肝素存在体液不耐受的患者发生了急性血栓形成，其中两例因未能确诊而死亡，一例留下明显后遗症，另外两例康复且无并发症。此类意外事件可能发生在0.6%接受肝素治疗的患者中，若不停用肝素，几乎总会致命。它们是由严重的免疫过敏反应导致的血小板减少引起的，这可能会导致动脉血栓形成。肝素治疗期间出现动脉血栓提示该诊断，有必要检测血小板计数是否减少。除手术外，治疗包括立即停止肝素治疗。
