Epstein L G, Prineas J W, Raine C S
J Neurol Sci. 1983 Oct-Nov;61(3):341-8. doi: 10.1016/0022-510x(83)90167-3.
In experimental allergic encephalomyelitis (EAE) invading macrophages appear to destroy the antigen-containing region of the plasma membrane of the myelinating cell, leaving the cell body intact. We report here that during myelin destruction and phagocytosis, myelin lamellae are attached to coated pits on the macrophage surface. As coated pits are sites where receptor-ligand complexes concentrate prior to endocytosis, we conclude that ligand-mediated phagocytosis may explain the targeted activity of macrophages in autoimmune demyelination.
在实验性变应性脑脊髓炎（EAE）中，侵入的巨噬细胞似乎会破坏髓鞘形成细胞质膜的含抗原区域，而细胞体保持完整。我们在此报告，在髓鞘破坏和吞噬过程中，髓鞘板层附着于巨噬细胞表面的被膜小窝。由于被膜小窝是受体 - 配体复合物在胞吞作用之前聚集的部位，我们得出结论，配体介导的吞噬作用可能解释了巨噬细胞在自身免疫性脱髓鞘中的靶向活性。
