Iwai N, Mizoguchi F, Sasaki A, Taneda Y, Nakamura H
Jpn J Antibiot. 1983 Aug;36(8):2242-60.
Fundamental and clinical studies of cefpiramide (CPM), a new cephem antibiotic, were carried out in the field of pediatrics. 80% MICs of CPM against S. aureus, S. pyogenes, H. influenzae, E. coli, K. pneumoniae and P. aeruginosa were 1.56, 0.05, 0.39, 6.25, 0.78 and 25 micrograms/ml, respectively. Serum concentration of CPM after intravenous injection at a dose of 20 mg/kg to 3 children was 103.7 +/- 9.1 micrograms/ml at 15 minutes and 13.4 +/- 5.0 micrograms/ml at 8 hours, with half-life of 3.11 +/- 0.83 hours. The excretion rate of CPM into urine was 16.40 +/- 7.31% within 8 hours. The transfer of CPM to cerebrospinal fluid was 0.1 approximately 0.2 micrograms/ml at 1 hour after intravenous injection at a dose of 20 mg/kg to patients with Aseptic meningitis, and 0.4 approximately 4.0 micrograms/ml at 1 hour approximately 3 hours 15 minutes after intravenous injection at a dose of 50 mg/kg to patients with purulent meningitis. Clinical effects of CPM on 37 patients with various infections were excellent in 28 cases, good in 6 cases, fair in 2 cases and poor in 1 case. The effective rate (excellent and good) was 91.9%. Bacteriologically, the eradication rate in 23 isolated organisms was 95.5%. No side effects and abnormalities of laboratory findings were noted. It was concluded that CPM has a broad spectrum antibacterial activity both in vitro and in vivo.
对新型头孢烯类抗生素头孢匹胺（CPM）进行了儿科领域的基础和临床研究。CPM对金黄色葡萄球菌、化脓性链球菌、流感嗜血杆菌、大肠杆菌、肺炎克雷伯菌和铜绿假单胞菌的80% MIC分别为1.56、0.05、0.39、6.25、0.78和25微克/毫升。给3名儿童静脉注射20毫克/千克剂量的CPM后，15分钟时血清浓度为103.7±9.1微克/毫升，8小时时为13.4±5.0微克/毫升，半衰期为3.11±0.83小时。CPM在8小时内的尿排泄率为16.40±7.31%。对于无菌性脑膜炎患者，静脉注射20毫克/千克剂量后1小时，CPM向脑脊液的转移量约为0.1至0.2微克/毫升；对于化脓性脑膜炎患者，静脉注射50毫克/千克剂量后1小时至3小时15分钟，转移量为0.4至4.0微克/毫升。CPM对37例各种感染患者的临床疗效，28例为优，6例为良，2例为中，1例为差。有效率（优和良）为91.9%。从细菌学角度看，23株分离菌的根除率为95.5%。未观察到副作用和实验室检查异常。结论是CPM在体外和体内均具有广谱抗菌活性。
