组胺H1和H2受体阻断对犬胃酸分泌的影响。
Effect of histamine H1- and H2-receptor blockade on canine gastric acid secretion.
作者信息
Barbezat G O, Bowey F S, Kaplan E R, Hickman R
出版信息
Am J Dig Dis. 1978 Mar;23(3):222-4. doi: 10.1007/BF01072321.
PMID:665610
Abstract
In dogs with gastric fistulae and Heidenhain pouches, inhibition of histamine-stimulated gastric acid secretion by the histamine H2-receptor antagonist metiamide is not increased by the addition of a histamine H1-receptor antagonist (mepyramine maleate). Under the conditions of this study there is no evidence for the presence of histamine H1-receptor sites on the gastric parietal cell.
摘要
在患有胃瘘和海登海因小胃的狗中，组胺H2受体拮抗剂甲硫米特对组胺刺激的胃酸分泌的抑制作用，不会因添加组胺H1受体拮抗剂（马来酸美吡拉敏）而增强。在本研究条件下，没有证据表明胃壁细胞上存在组胺H1受体位点。
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