[流感病毒减毒过程中RNA的结构变化]
[Structural changes in influenza virus RNA during its attenuation].
作者信息
Zhilinskaia N N, Kozlov Iu V, Kurmanova A G, Rumovskiĭ V I, Baev A A
出版信息
Mol Biol (Mosk). 1983 Nov-Dec;17(6):1171-6.
PMID:6656749
Abstract
Changes in structures of only two genes of influenza virus--M and NS genes were found during virus attenuation by the method of oligonucleotide mapping. Such changes were observed in virulent and attenuated viruses (passages 10-23 in chick embryos) by comparing intermediate variants of the virus (passages 11-16 in chick embryos). These results allow us to conclude the important role of these genes in virus attenuation and in connection with virulence of the virus.
摘要
通过寡核苷酸图谱法对流感病毒进行减毒时，发现仅病毒的两个基因——M基因和NS基因的结构发生了变化。通过比较病毒的中间变体（鸡胚传代11 - 16代），在强毒株和减毒株（鸡胚传代10 - 23代）中均观察到了这种变化。这些结果使我们能够得出结论，这些基因在病毒减毒以及与病毒毒力的关联中起着重要作用。
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