Perkins S N, Evans W S, Thorner M O, Cronin M J
Neuroendocrinology. 1983 Dec;37(6):473-5. doi: 10.1159/000123597.
Perifusion of dispersed rat anterior pituitary cells with pulses of the beta-adrenergic agonists isoproterenol and epinephrine resulted in a prompt, but brief, rise in growth hormone release. This effect was blocked by propranolol, a beta-adrenergic antagonist, but not phentolamine, an alpha-adrenergic antagonist. These results, in conjunction with other recent reports, suggest that epinephrine may act directly at the anterior pituitary gland as a physiological growth hormone-releasing factor.
用β-肾上腺素能激动剂异丙肾上腺素和肾上腺素脉冲对分散的大鼠垂体前叶细胞进行灌流，导致生长激素释放迅速但短暂地升高。这种效应被β-肾上腺素能拮抗剂普萘洛尔阻断，但未被α-肾上腺素能拮抗剂酚妥拉明阻断。这些结果与最近的其他报道一起表明，肾上腺素可能作为一种生理性生长激素释放因子直接作用于垂体前叶。
