喷他佐辛和曲吡那敏对镇痛的影响。

Effects of pentazocine and tripelennamine on analgesia.

作者信息

Cleary J, Wallace S, Grossett D, Picker M, Poling A

出版信息

Pharmacol Biochem Behav. 1983 Dec;19(16):911-5. doi: 10.1016/0091-3057(83)90389-1.

Abstract

The analgesic effects of pentazocine and tripelennamine, alone and in combination, were assessed in rats with a hot plate apparatus. In Experiment 1, the combination of tripelennamine with chronic pentazocine produced analgesia at doses which were not analgesic when the drugs were given alone. This combination also reestablished analgesia in subjects made tolerant to pentazocine's effects. In Experiment 2, development of tolerance to the analgesic effects of pentazocine was delayed by addition of tripelennamine. These data may contribute to a rationale for the current popularity of combined pentazocine and tripelennamine abuse.

摘要

采用热板装置在大鼠中评估喷他佐辛和曲吡那敏单独及联合使用时的镇痛效果。在实验1中，曲吡那敏与慢性给予喷他佐辛的组合在单独给药时无镇痛作用的剂量下产生了镇痛效果。这种组合还使对喷他佐辛作用产生耐受性的受试者重新建立了镇痛作用。在实验2中，加入曲吡那敏可延缓对喷他佐辛镇痛作用耐受性的产生。这些数据可能为当前喷他佐辛和曲吡那敏联合滥用的流行提供理论依据。