Pappas B A, Walsh P
Pharmacol Biochem Behav. 1983 Dec;19(6):957-61. doi: 10.1016/0091-3057(83)90398-2.
The effects of various doses of pentylenetetrazol, clonidine, chlordiazepoxide and diazepam on limb and head movement and behavioral seizure signs were examined in 4-, 8- and 16-day old rats tested at ambient temperatures of either 25 or 35 degrees C. All 4 drugs produced intense behavioral activation at the 2 younger ages but there were marked differences among them in the effects of test temperature on this activation and in the relationship between age and their activating effect. A "paradoxical" and intense behavioral energization was observed after the administration of either of the 2 benzodiazepines at 4, 8 but not 16 days, particularly at the lower test temperature. Clonidine and pentylenetetrazol were activating at all 3 ages but while clonidine had greater effect at the low test temperature, the opposite was the case after pentylenetetrazol. The effects of the benzodiazepines and clonidine were clearly distinct from those of pentylenetetrazol and this was the only drug to substantially elicit seizure signs. It is uncertain whether or not the benzodiazepines cause brain seizures in young animals. If so, then their behavioral manifestation is clearly different from that observed after pentylenetetrazol.
在环境温度为25摄氏度或35摄氏度的条件下，对4日龄、8日龄和16日龄的大鼠进行了实验，研究了不同剂量的戊四氮、可乐定、氯氮卓和地西泮对肢体与头部运动以及行为性癫痫发作体征的影响。在较年幼的两个年龄段，所有这4种药物均产生强烈的行为激活作用，但它们在测试温度对这种激活作用的影响以及年龄与其激活作用之间的关系方面存在显著差异。在4日龄和8日龄而非16日龄时，尤其是在较低的测试温度下，给予两种苯二氮卓类药物中的任何一种后，均观察到一种“矛盾的”且强烈的行为兴奋。可乐定和戊四氮在所有3个年龄段均具有激活作用，但可乐定在低测试温度下作用更强，而戊四氮则相反。苯二氮卓类药物和可乐定的作用明显不同于戊四氮，戊四氮是唯一能显著引发癫痫发作体征的药物。尚不确定苯二氮卓类药物是否会在幼龄动物中引发脑部癫痫发作。如果会，那么其行为表现明显不同于戊四氮给药后观察到的情况。
