冠状动脉内给予白三烯D4对麻醉犬的影响。

Effects of intra-coronary administration of leukotriene D4 in the anaesthetized dog.

作者信息

Letts L G, Newman D L, Greenwald S E, Piper P J

出版信息

Prostaglandins. 1983 Oct;26(4):563-72. doi: 10.1016/0090-6980(83)90194-6.

Abstract

The left anterior descending coronary artery in anaesthetized greyhounds was perfused at constant pressure with blood pumped from the carotid artery. Phasic and mean coronary flow, left ventricular pressure, dP/dt, cardiac output, ECG, heart rate and systemic pressure were measured. Leukotriene (LT) D4 was administered into the left anterior descending coronary artery as a bolus injection. LTD4 caused dose-related reductions in coronary flow. Other parameters showed little immediate change although a gradual decrease in left ventricular pressure, dP/dt, cardiac output and systemic pressure occurred after administration of LTD4. Following intracoronary administration of LTD4 small surface haemorrhages were observed over the area perfused. The reduction in coronary flow was not inhibited by indomethacin.

摘要

在麻醉的灵缇犬中，用从颈动脉泵出的血液以恒定压力灌注左前降支冠状动脉。测量了冠状动脉的搏动血流和平均血流、左心室压力、dP/dt、心输出量、心电图、心率和体循环压力。白三烯（LT）D4作为单次注射注入左前降支冠状动脉。LTD4导致冠状动脉血流呈剂量相关减少。其他参数虽在LTD4给药后左心室压力、dP/dt、心输出量和体循环压力逐渐下降，但几乎没有立即变化。冠状动脉内给予LTD4后，在灌注区域观察到小面积表面出血。吲哚美辛未抑制冠状动脉血流的减少。