Gantchev G N, Draganova N
Acta Physiol Pharmacol Bulg. 1983;9(2):43-50.
The post-stimulus inhibition of the H-reflex was studied in human subjects with the following experimental sets: Presentation of a pair of stimuli, with intensity of the conditioned stimulus, S1, of 30% Hmax, and with varying intensities of the test stimulus, S2, from threshold to maximal values. Varying intensity of S1 from threshold values, 30% Hmax, 50% Hmax, and varying intensity of S2 from threshold to maximal values, for the H2-reflex-curve to be obtained. Varying intensity of S1 from 0.9 to 1.15-1.20 threshold and constant intensity of S2 of 30-40% Hmax. In the first two experiments the curve "intensity of S1/H2-reflex amplitude" at different intensities of S1 and different delays of S2 has been investigated. In the third experiment the H2-reflex recovery with diminishing the S1 to subthreshold values has been investigated. The results have shown: H2-reflex was strongly suppressed even with threshold values of S1. H2-reflex-curve after a conditioned stimulus was significantly lower to the H-reflex-curve after a single stimulus. The recovery of the H-reflex amplitude after S1 was observed with subthreshold values of S1. The possible role of the presynaptic inhibition for the suppression of the H1-reflex with the presentation of a pair of stimuli has been considered.
在人类受试者中,通过以下实验设置研究了H反射的刺激后抑制:呈现一对刺激,条件刺激S1的强度为最大Hoffmann反应(Hmax)的30%,测试刺激S2的强度从阈值到最大值变化。将S1的强度从阈值、30%Hmax、50%Hmax变化,S2的强度从阈值到最大值变化,以获得H2反射曲线。将S1的强度从0.9至1.15 - 1.20阈值变化,S2的强度保持在30 - 40%Hmax不变。在前两个实验中,研究了在不同S1强度和不同S2延迟下的“S1强度/H2反射幅度”曲线。在第三个实验中,研究了将S1降低至阈下值时H2反射的恢复情况。结果表明:即使S1为阈值强度,H2反射也受到强烈抑制。条件刺激后的H2反射曲线明显低于单次刺激后的H反射曲线。当S1为阈下值时,观察到了H反射幅度的恢复。已经考虑了突触前抑制在呈现一对刺激时对H1反射抑制的可能作用。