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老年人帕金森综合征的诊断与管理

Diagnosis and management of parkinsonism in the elderly.

作者信息

Turnbull C J, Aitken J A

出版信息

Age Ageing. 1983 Nov;12(4):309-16. doi: 10.1093/ageing/12.4.309.

Abstract

Of 123 patients with parkinsonism attending a department of medicine for the elderly who were assessed, 73% were thought to have idiopathic Parkinson's disease, and 91% of these cases and 52% of the remaining cases had a history of rest tremor; 34% of all cases were demented. The prevalence of dementia did not correlate with the duration of disease. Demented patients with presumed idiopathic Parkinson's disease were not distinguishable from non-demented by duration of disease, presence of a history of rest tremor or use of L-dopa. Eighty-eight per cent of non-demented patients but only 44% of demented patients were thought to have responded to L-dopa. Lower doses of L-dopa were used than are conventional with younger patients.

摘要

在一家老年医学科接受评估的123例帕金森综合征患者中,73%被认为患有特发性帕金森病,其中91%的病例和其余病例的52%有静止性震颤病史;所有病例中有34%患有痴呆。痴呆的患病率与病程无关。推定患有特发性帕金森病的痴呆患者与非痴呆患者在病程、静止性震颤病史或使用左旋多巴方面没有区别。88%的非痴呆患者被认为对左旋多巴有反应,而痴呆患者中这一比例仅为44%。与年轻患者相比,左旋多巴的使用剂量较低。

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