Tabbara W S, Aftimos G P
Ann Anat Pathol (Paris). 1978;23(1):53-61.
The authors present two observations of angiomyolipoma of the kidney one of which bilateral and multicentric. They analyse the clinical manifestations and the morphologic features of these tumors in a review of the litterature and insist on the frequency and the seriousness of hemorragic complications that may result in medical emergencies. The histogenesis of these hamartomas is considered and the underlying genetic disorders are discussed. The surgical treatment is discussed in considering the possible bilateral localizations and the common age incidence with Grawitz's tumor. The authors admit the benign nature of angiomyolipomas and give little credit to frozen-section diagnosis because of the frequent occurence of cellular atypias in these tumors.
作者报告了两例肾血管平滑肌脂肪瘤的观察病例，其中一例为双侧多中心性。他们在回顾文献时分析了这些肿瘤的临床表现和形态学特征，并强调了可能导致医疗急症的出血并发症的发生率和严重性。文中考虑了这些错构瘤的组织发生，并讨论了潜在的遗传紊乱。在考虑到可能的双侧定位以及与肾上腺皮质癌的共同发病年龄时，讨论了手术治疗。作者承认血管平滑肌脂肪瘤的良性性质，并因这些肿瘤中细胞异型性的频繁出现而不太认可冰冻切片诊断。
