Craig T M, Bell R R
Am J Vet Res. 1978 Jun;39(6):1037-8.
Calves naturally infected with Ostertagia, Haemonchus, Trichostrongylus, and Cooperia were used in a controlled experiment to determine the anthelmintic efficacy of fenbendazole, methyl-5-(phenylthio)-2-benzimidazolecarbamate, and to compare this with the efficacy of levamisole. The calves were placed in dry lots for approximately 3 weeks, ensuring that immature Ostertagia larvae were in arrested development before the calves were treated. In calves given doses of 8 mg of levamisole/kg of body weight and 5 and 7.5 mg of fenbendazole/kg, reductions of adult Ostertagia were 95%, 99%, and 99% respectively. Reductions of developing Ostertagia L4 were 29%, 99%, and 100%; of arrested Ostertagia L4--5%, 24%, and 72%; of adult Haemonchus--97%, 100%, and 100%; of adult Trichostrongylus--97%, 99%, and 100%, and of adult Cooperia--100%, 100%, and 100%--as compared with data in untreated controls.
选用自然感染奥斯特他线虫、血矛线虫、毛圆线虫和古柏线虫的犊牛进行对照试验，以测定芬苯达唑、5-（苯硫基）-2-苯并咪唑氨基甲酸甲酯的驱虫效果，并与左旋咪唑的效果进行比较。将犊牛置于干燥场地约3周，确保在犊牛接受治疗前未成熟的奥斯特他线虫幼虫处于发育停滞状态。给犊牛分别按每千克体重8毫克左旋咪唑、5毫克和7.5毫克芬苯达唑的剂量给药后，成虫奥斯特他线虫的减少率分别为95%、99%和99%。发育中的奥斯特他线虫L4的减少率分别为29%、99%和100%；停滞的奥斯特他线虫L4的减少率分别为5%、24%和72%；成虫血矛线虫的减少率分别为97%、100%和100%；成虫毛圆线虫的减少率分别为97%、99%和100%；成虫古柏线虫的减少率分别为100%、100%和100%，与未治疗对照组的数据相比。
