Breznock E M, Kagan K G, Attix E S
Am J Vet Res. 1978 Jun;39(6):977-80.
A dose-response curve was delineated for an acetylcholine-potassium chloride cocktail previously found to be highly effective in chemically defibrillating electrical induced ventricular fibrillation of thoracotomized dogs. The cocktail dosage responsible for the greatest percentage of chemical defibrillations was transthoracically given to nonthoracotomized dogs subjected to ventricular fibrillation; this resulted in 33% chemical defibrillation. Two clinical canine patients were transthoracically administered the acetylcholine-potassium chloride cocktail because they failed to respond to external electrical defibrillation; both were chemically defibrillated. Potassium citrate when substituted for potassium chloride, in the cocktail, or alone appeared to be more efficacious for chemical defibrillation. Magnesium chloride with acetylcholine failed to chemically defibrillate any dog administered this cocktail.
针对一种乙酰胆碱 - 氯化钾混合液绘制了剂量反应曲线，该混合液先前被发现对开胸犬的电诱导心室颤动进行化学除颤非常有效。将导致最大比例化学除颤的混合液剂量经胸给予发生心室颤动的非开胸犬；这导致了33%的化学除颤成功率。两名临床犬科患者因对外部电除颤无反应而经胸给予乙酰胆碱 - 氯化钾混合液；两者均实现了化学除颤。当在混合液中用柠檬酸钾替代氯化钾时，或单独使用柠檬酸钾时，似乎对化学除颤更有效。乙酰胆碱与氯化镁混合使用时，未能使任何接受该混合液的犬实现化学除颤。
