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Evidence for the metabolic formation of a vicinal dihydrodiol-epoxide from the potent mutagen 1-nitrobenzo(A)pyrene.

作者信息

Chou M W, Fu P P

出版信息

Biochem Biophys Res Commun. 1983 Dec 16;117(2):541-8. doi: 10.1016/0006-291x(83)91234-2.

DOI:10.1016/0006-291x(83)91234-2
PMID:6661241
Abstract

Metabolism of 1-nitrobenzo(a)pyrene (1-nitro-BaP) by rat liver microsomes yielded 1-nitro-BaP trans-7,8-dihydrodiol, 1-nitro-BaP trans-9,10-dihydrodiol and 1-nitro-BaP 7,8,9,10-tetrahydrotetrol. Formation of these metabolites suggests that a vicinal 7,8,9,10-dihydrodiol-epoxide is a metabolite of 1-nitro-BaP.

摘要

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