氟西泮和溴替唑仑对精神运动表现的残留影响。
Residual effects of flurazepam and brotizolam on psychomotor performance.
作者信息
Krueger H, Müller-Limmroth W
出版信息
Br J Clin Pharmacol. 1983;16 Suppl 2(Suppl 2):347S-351S. doi: 10.1111/j.1365-2125.1983.tb02309.x.
Residual effects of brotizolam (0.25 mg) and flurazepam (30 mg) were studied in healthy young adults. Performance and subjective assessments were observed from 7 to 8 h after overnight ingestion, and effects were compared with that of placebo. Visuo-motor coordination, visuo-mental processing time, visuo-motor reaction time and reading errors were not impaired with brotizolam. There were residual effects with 30 mg flurazepam. Visuo-motor coordination, visuo-mental processing time, visuo-motor reaction time, and reading errors were impaired compared with placebo and 0.25 mg brotizolam. Subjective assessments of performance correlated with measured performance. There was a decrease with flurazepam (visuo-motor coordination and visuo-mental processing time) compared with placebo.
在健康的年轻成年人中研究了溴替唑仑（0.25毫克）和氟西泮（30毫克）的残留效应。在夜间服药后7至8小时观察了表现和主观评估，并将其效果与安慰剂进行了比较。溴替唑仑未损害视觉运动协调性、视觉心理加工时间、视觉运动反应时间和阅读错误。30毫克氟西泮有残留效应。与安慰剂和0.25毫克溴替唑仑相比，视觉运动协调性、视觉心理加工时间、视觉运动反应时间和阅读错误均受到损害。对表现的主观评估与测量的表现相关。与安慰剂相比，氟西泮（视觉运动协调性和视觉心理加工时间）有所下降。
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