Rosenberg R C
Biochim Biophys Acta. 1983 Dec 28;749(3):276-80. doi: 10.1016/0167-4838(83)90236-4.
The inhibition of bovine dopamine beta-hydroxylase (dopamine beta-monooxygenase, EC 1.14.17.1) by 2-mercapto-1-methylimidazole has been studied using a simple, 'metal-free' assay system. 2-Mercapto-1-methylimidazole is an uncompetitive inhibitor of dopamine beta-hydroxylase with respect to ascorbate and a mixed type of inhibitor with respect to tyramine. These findings are consistent with 2-mercapto-1-methylimidazole interacting exclusively with the reduced form of dopamine beta-hydroxylase.
利用一种简单的“无金属”检测系统，研究了2-巯基-1-甲基咪唑对牛多巴胺β-羟化酶（多巴胺β-单加氧酶，EC 1.14.17.1）的抑制作用。2-巯基-1-甲基咪唑是多巴胺β-羟化酶相对于抗坏血酸的非竞争性抑制剂，相对于酪胺是混合型抑制剂。这些发现与2-巯基-1-甲基咪唑仅与多巴胺β-羟化酶的还原形式相互作用一致。
