[纳洛酮在创伤性休克中的作用]
[Effect of naloxone in traumatic shock].
作者信息
Iasnetsov V V, Motin V G
出版信息
Biull Eksp Biol Med. 1983 Dec;96(12):50-2.
PMID:6661548
Abstract
Experiments on rabbits were made to examine the effect of naloxone, a specific antagonist of opiates and endogenous opioid peptides, on traumatic shock. Naloxone (0.1-1.0 mg/kg) injected intravenously 2-15 minutes after trauma produced no effect on the arterial pressure and the heart rate. As compared with control animals, the lifespan of animals with trauma decreased. It is suggested that endogenous opioid peptides may play a protective and adaptive role in the torpid phase of traumatic shock.
摘要
进行了兔实验，以研究阿片类药物及内源性阿片肽的特异性拮抗剂纳洛酮对创伤性休克的影响。创伤后2至15分钟静脉注射纳洛酮（0.1 - 1.0毫克/千克）对动脉血压和心率无影响。与对照动物相比，创伤动物的存活时间缩短。提示内源性阿片肽在创伤性休克的迟钝期可能起保护和适应性作用。
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