Briel R C
Int Surg. 1983 Jul-Sep;68(3):241-3.
In a randomized study, 124 patients, undergoing abdominal hysterectomy, were examined for postoperative wound hematoma after receiving low-dose heparin or heparin-dihydroergotamin (DHE) prophylaxis. Different sites of injection were chosen, with or without subcutaneous administration of thrombin at the end of surgery. The postoperative incidence of wound hematoma was not improved by subcutaneous thrombin administration. There was no difference between the two types of prophylaxis. When heparin or heparin/DHE was injected in the upper arm, however, fewer hematomas were found than after injection in the abdominal region. Investigations of the coagulation and fibrinolytic systems showed no difference between the two types of prophylaxis and injection site. The administration of thrombin did not cause intravascular activation of the coagulation system.
在一项随机研究中，对124例行腹部子宫切除术的患者在接受低剂量肝素或肝素-双氢麦角胺（DHE）预防后检查术后伤口血肿情况。选择不同的注射部位，手术结束时皮下给予或不给予凝血酶。皮下给予凝血酶并未改善术后伤口血肿的发生率。两种预防方式之间没有差异。然而，当在上臂注射肝素或肝素/DHE时，发现的血肿比在腹部区域注射后更少。对凝血和纤溶系统的研究表明，两种预防方式和注射部位之间没有差异。凝血酶的给药未引起凝血系统的血管内激活。
