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基于铝镁加的新型抗酸剂配方的比较评估

A comparative assessment of a new antacid formulation based on magaldrate.

作者信息

McCafferty D F, Woolfson A D

出版信息

J Clin Hosp Pharm. 1983 Dec;8(4):349-55. doi: 10.1111/j.1365-2710.1983.tb01058.x.

DOI:10.1111/j.1365-2710.1983.tb01058.x
PMID:6662972
Abstract

A new antacid formulation (Dynese) based on magaldrate, a discrete chemical entity with marked antacid properties, has been compared in vitro with several commercially available antacid preparations. All preparations were tested for their ability to maintain gastric pH within acceptable limits and to effectively bind bile acids. Sodium concentrations were also determined. Dynese was shown to compare very favourably with existing preparations in that it had a prolonged even neutralization profile, efficient bile acid binding properties and a low sodium content.

摘要

一种基于氢氧化铝镁的新型抗酸剂配方(Dynese),氢氧化铝镁是一种具有显著抗酸特性的离散化学实体,已在体外与几种市售抗酸剂制剂进行了比较。所有制剂都测试了其将胃pH值维持在可接受范围内以及有效结合胆汁酸的能力。还测定了钠浓度。结果表明,Dynese与现有制剂相比具有很大优势,因为它具有延长的均匀中和曲线、有效的胆汁酸结合特性和低钠含量。

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