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磺苄西林及其代谢产物对血小板功能的抑制作用。

Inhibition of platelet function by sulbenicillin and its metabolite.

作者信息

Ikeda Y, Kikuchi M, Matsuda S, Toyama K, Hasegawa M, Watanabe K, Ando Y

出版信息

Antimicrob Agents Chemother. 1978 May;13(5):881-3. doi: 10.1128/AAC.13.5.881.

DOI:10.1128/AAC.13.5.881
PMID:666307
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC352348/
Abstract

The effect of sulbenicillin and its major metabolite, alpha-sulfobenzylpenicilloic acid, on platelet function was investigated. Sulbenicillin caused inhibition of platelet aggregation and release reaction in the same manner as carbenicillin. alpha-Sulfobenzylpenicilloic acid was found to cause much stronger inhibition of platelet function. The results indicate that the strong inhibitory action of alpha-sulfobenzylpenicilloic acid may also take part in impaired platelet functions following administration of sulbenicillin to humans.

摘要

研究了磺苄西林及其主要代谢产物α-磺苄青霉素酸对血小板功能的影响。磺苄西林对血小板聚集和释放反应的抑制作用与羧苄西林相同。发现α-磺苄青霉素酸对血小板功能的抑制作用更强。结果表明，α-磺苄青霉素酸的强烈抑制作用也可能参与了人体使用磺苄西林后血小板功能受损的过程。

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Inhibition of platelet function by sulbenicillin and its metabolite.磺苄西林及其代谢产物对血小板功能的抑制作用。
Antimicrob Agents Chemother. 1978 May;13(5):881-3. doi: 10.1128/AAC.13.5.881.
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本文引用的文献

1
Aggregation of blood platelets by adenosine diphosphate and its reversal.二磷酸腺苷引起的血小板聚集及其逆转
Nature. 1962 Jun 9;194:927-9. doi: 10.1038/194927b0.
2
The release of nucleotides, 5-hydroxytryptamine and enzymes from human blood platelets during aggregation.人血小板聚集过程中核苷酸、5-羟色胺及酶的释放。
J Physiol. 1968 Apr;195(3):715-29. doi: 10.1113/jphysiol.1968.sp008484.
3
The metabolic fate of -sulphobenzylpenicillin in rats.大鼠体内磺苄青霉素的代谢归宿
Xenobiotica. 1972 Mar;2(2):147-57. doi: 10.3109/00498257209111046.
4
The hemostatic defect produced by carbenicillin.羧苄青霉素产生的止血缺陷。
N Engl J Med. 1974 Aug 8;291(6):265-70. doi: 10.1056/NEJM197408082910601.
5
Carbenicillin in renal failure.肾衰竭中的羧苄青霉素。
Lancet. 1970 Aug 22;2(7669):422.
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Carbenicillin-induced bleeding disorder.
Lancet. 1970 Dec 19;2(7686):1307-8. doi: 10.1016/s0140-6736(70)92264-6.
7
Study of the effects of ticarcillin on blood coagulation and platelet function.替卡西林对血液凝固及血小板功能影响的研究。
Antimicrob Agents Chemother. 1975 May;7(5):652-7. doi: 10.1128/AAC.7.5.652.
8
Effects of cephalothin and penicillin G on platelet function in vitro.
Br J Haematol. 1977 Jan;35(1):135-52. doi: 10.1111/j.1365-2141.1977.tb00569.x.

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