Inhibition of platelet function by sulbenicillin and its metabolite.
作者信息
Ikeda Y, Kikuchi M, Matsuda S, Toyama K, Hasegawa M, Watanabe K, Ando Y
出版信息
Antimicrob Agents Chemother. 1978 May;13(5):881-3. doi: 10.1128/AAC.13.5.881.
Abstract
The effect of sulbenicillin and its major metabolite, alpha-sulfobenzylpenicilloic acid, on platelet function was investigated. Sulbenicillin caused inhibition of platelet aggregation and release reaction in the same manner as carbenicillin. alpha-Sulfobenzylpenicilloic acid was found to cause much stronger inhibition of platelet function. The results indicate that the strong inhibitory action of alpha-sulfobenzylpenicilloic acid may also take part in impaired platelet functions following administration of sulbenicillin to humans.
摘要
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Inhibition of platelet function by sulbenicillin and its metabolite.
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