Maloteaux J M, Laterre C E, Hens L, Laduron P M
J Neurol Neurosurg Psychiatry. 1983 Dec;46(12):1146-8. doi: 10.1136/jnnp.46.12.1146.
[3H]-spiperone binding on human lymphocytes did not reveal the occurrence of dopamine receptors. However, lower values were observed in Parkinsonism and the displaceable binding was increased after levodopa treatment although this was not specific only for levodopa and, furthermore, was not correlated with the clinical symptomatology. This non-specific binding in lymphocytes corresponds to trapping, presumably in lysosomes and thus does not reflect the dopaminergic receptors state in Parkinson's disease.
[3H]-司哌罗宁与人淋巴细胞的结合未显示多巴胺受体的存在。然而，在帕金森病患者中观察到较低的值，左旋多巴治疗后可置换结合增加，尽管这并非左旋多巴所特有，此外，也与临床症状无关。淋巴细胞中的这种非特异性结合对应于（药物）捕获，推测是在溶酶体中，因此不能反映帕金森病中多巴胺能受体的状态。
