Suzuki M, Kajuu T
J Nutr Sci Vitaminol (Tokyo). 1983 Oct;29(5):553-62. doi: 10.3177/jnsv.29.553.
This study was conducted to know the possibility that pectin-induced alterations in lipid metabolism of animals might be partly ascribed to galacturonic acid produced by the degradation of ingested pectin in the digestive tract. After a 4-week meal feeding twice a day, fasted rats were fed glucose and fructose and 3 h later orally administered 213 mg of pectin (from apple) or galacturonic acid per kg of body weight, or fed water alone. Significant changes in serum and liver lipids were observed 30 min and 1 h after the administration of pectin and galacturonic acid but not 5 h after the administration. Pectin and galacturonic acid showed contradictory effects on serum lipids, adipose tissue lipoprotein lipase activity and triacylglycerol (TG) production and removal rates. However, the elevation of total lipid and TG levels in liver with the sugar feeding was significantly inhibited by the administration of either pectin or galacturonic acid. These results support our hypothesis that galacturonic acid produced by the degradation of ingested pectin in the digestive tract may be partly responsible for the pectin-induced changes in lipid metabolism. This was discussed in relation to another possible regulation of lipid metabolism by short-chain fatty acids which are produced by the intestinal fermentation of pectin and galacturonic acid.
本研究旨在了解果胶引起动物脂质代谢改变可能部分归因于消化道中摄入的果胶降解产生的半乳糖醛酸这一可能性。在每天喂食两次、持续4周后，禁食的大鼠被喂食葡萄糖和果糖，3小时后每千克体重口服213毫克果胶（来自苹果）或半乳糖醛酸，或仅喂水。在给予果胶和半乳糖醛酸后30分钟和1小时观察到血清和肝脏脂质有显著变化，但给药5小时后未观察到。果胶和半乳糖醛酸对血清脂质、脂肪组织脂蛋白脂肪酶活性以及三酰甘油（TG）的产生和清除率表现出相反的作用。然而，喂食糖类后肝脏中总脂质和TG水平的升高被给予果胶或半乳糖醛酸显著抑制。这些结果支持了我们的假设，即消化道中摄入的果胶降解产生的半乳糖醛酸可能部分导致了果胶引起的脂质代谢变化。这与果胶和半乳糖醛酸在肠道发酵产生的短链脂肪酸对脂质代谢的另一种可能调节有关。
