Samoto T, Kobayashi S, Masaoka A, Nakamura T, Miura K
Gan No Rinsho. 1983 Nov;29(14):1682-5.
A case of breast cancer with cartilage-like structure is presented. The stroma, resembling cartilagenous martrix upon hematoxylin and eosin staining, showed metachromasia upon toluidine blue staining. However, predigestion with hyaluronidase or chondroitinase ABC revealed no change in toluidine blue (pH 2.5) staining, suggesting the absence of not only hyaluronic acid but also of chondroitin sulfate in this structure. It is therefore reasonable to conclude that the cartilage-like structure found in this case may have been derived from epithelial mucinous substances, similar to those observed in common mucinous carcinoma of the breast.
本文报告一例具有软骨样结构的乳腺癌病例。苏木精-伊红染色显示，基质类似于软骨基质，甲苯胺蓝染色呈异染性。然而，用透明质酸酶或硫酸软骨素酶ABC预消化后，甲苯胺蓝（pH 2.5）染色无变化，提示该结构中不仅不存在透明质酸，也不存在硫酸软骨素。因此，可以合理推断，该病例中发现的软骨样结构可能源自上皮黏液物质，类似于在常见乳腺黏液癌中观察到的物质。
