Feuerstein G, Faden A I
Life Sci. 1983;33 Suppl 1:731-4. doi: 10.1016/0024-3205(83)90606-9.
Cardiovascular and sympathetic responses to hypothalamic injections of dermorphin were studied in conscious rats. Microinjections of 10 pmol of dermorphin into the nucleus preopticus medialis (POM) elicited tachycardia without changing the mean blood pressure (MBP). A higher dose of dermorphin (100 pmol) caused prolonged tachycardia, and an increase in MBP. The pressor/tachycardic period following injection of 100 pmol dermorphin was accompanied by increased levels of plasma norepinephrine and epinephrine. These data suggest that the POM region is an important site for sympathetic activation and pressor/tachycardic effects of dermorphin.
在清醒大鼠中研究了下丘脑注射德莫啡肽后的心血管和交感神经反应。向内侧视前核（POM）微量注射10皮摩尔德莫啡肽可引起心动过速，而平均血压（MBP）无变化。更高剂量的德莫啡肽（100皮摩尔）可导致心动过速持续时间延长以及MBP升高。注射100皮摩尔德莫啡肽后的升压/心动过速期伴随着血浆去甲肾上腺素和肾上腺素水平升高。这些数据表明，POM区域是德莫啡肽交感神经激活和升压/心动过速效应的重要部位。
