印防己毒素抑制乙醇对来自大鼠纹状体灌流切片的[3H] - 多巴胺自发外流的影响。

Picrotoxin inhibits the effect of ethanol on the spontaneous efflux of [3H]-dopamine from superfused slices of rat corpus striatum.

作者信息

Samuel D, Lynch M A, Littleton J M

出版信息

Neuropharmacology. 1983 Dec;22(12A):1413-5. doi: 10.1016/0028-3908(83)90234-4.

Abstract

The presence of ethanol, 100 microM, in the superfusate enhanced the spontaneous release of previously uptaken [3H]-dopamine from slices of rat corpus striatum, but produced a small inhibition of K+-stimulated release. The concomitant presence of picrotoxin, 10 microM, in the superfusate prevented the enhancement of spontaneous release of [3H]-dopamine by ethanol with equivocal effects on K+-stimulated release. When present in the superfusate alone picrotoxin had no effect on [3H]-dopamine release.

摘要

在灌流液中存在100微摩尔的乙醇，可增强大鼠纹状体切片中先前摄取的[3H] -多巴胺的自发释放，但对钾离子刺激的释放产生轻微抑制。灌流液中同时存在10微摩尔的苦味毒，可阻止乙醇增强[3H] -多巴胺的自发释放，对钾离子刺激的释放影响不明确。当苦味毒单独存在于灌流液中时，对[3H] -多巴胺的释放没有影响。