Starr M S
Eur J Pharmacol. 1978 Apr 1;48(3):325-8. doi: 10.1016/0014-2999(78)90091-2.
GABA (10-5--10-3 M) had no effect on the spontaneous outflow of previously accumulated 3H-DA or 3H-5HT from rat nigral or striatal slices. However, GABA markedly potentiated the potassium-stimulated release of 3H-DA in both brain regions, while the depolarization-induced output of 3H-5HT was only slightly increased. This action of GABA was blocked by pictotoxin but not by bicuculline. Amphetamine likewise evoked a dose-related efflux of 3H-DA and 3H-5HT from nigra and striatum, but these releases were unchanged by GABA. The data suggest that GABA acts presynaptically in these areas to regulate dopaminergic cell function.
γ-氨基丁酸（10⁻⁵ 至 10⁻³ 摩尔/升）对先前积累在大鼠黑质或纹状体切片中的³H-多巴胺或³H-5-羟色胺的自发流出没有影响。然而，γ-氨基丁酸在这两个脑区均显著增强了钾离子刺激的³H-多巴胺释放，而去极化诱导的³H-5-羟色胺释放仅略有增加。γ-氨基丁酸的这一作用被印防己毒素阻断，但不被荷包牡丹碱阻断。安非他命同样引起³H-多巴胺和³H-5-羟色胺从黑质和纹状体剂量相关的流出，但这些释放不受γ-氨基丁酸影响。数据表明，γ-氨基丁酸在这些区域通过突触前作用来调节多巴胺能细胞功能。
