升压反应性从肾性高血压大鼠向正常血压大鼠的被动转移。

Passive transfer of pressor hyperresponsiveness from renal-hypertensive to normotensive rats.

作者信息

Simon G

出版信息

Proc Soc Exp Biol Med. 1983 Dec;174(3):356-62. doi: 10.3181/00379727-174-41748.

Abstract

The role of serum factors in the pathogenesis of pressor hyperresponsiveness in hypertension was investigated by the passive transfer of serum from donor rats with chronic one-kidney, one clip hypertension into syngeneic normotensive recipient rats (0.25 ml iv, bid) for 3 weeks. Rats injected twice daily with the serum of normotensive rats served as controls. In rats injected with the serum of hypertensive rats there was a gradual increase in pressor responses to norepinephrine and angiotensin II and, at the end of the study, increased water content of the aorta and sodium content of the myocardium. In volume-expanded renal hypertension unidentified serum factors contribute to pressor hyperresponsiveness and increased sodium content of cardiovascular tissue.

摘要

通过将患有慢性单肾单夹高血压的供体大鼠的血清被动转移至同基因正常血压受体大鼠体内（静脉注射0.25 ml，每日两次），持续3周，研究了血清因子在高血压中升压反应性发病机制中的作用。每日两次注射正常血压大鼠血清的大鼠作为对照。在注射高血压大鼠血清的大鼠中，对去甲肾上腺素和血管紧张素II的升压反应逐渐增加，并且在研究结束时，主动脉含水量增加，心肌钠含量增加。在容量扩张性肾性高血压中，未明确的血清因子导致升压反应性增加以及心血管组织钠含量增加。