Ramirez I, Friedman M I
Physiol Behav. 1983 Dec;31(6):847-50. doi: 10.1016/0031-9384(83)90282-2.
The mechanisms by which fat feeding suppresses the hyperphagia of diabetic rats were examined. Rats that were allowed to consume a small amount (1.5 ml) of corn oil decreased subsequent food intake within 6 hr after ingesting. Diabetic rats decreased food intake much more than normal rats. Similar results were obtained when oil was given intragastrically. Analysis of blood samples revealed that diabetic rats showed greater increases in plasma ketones and triglycerides and smaller increases in plasma glycerol than normal rats following consumption of 1.5 ml corn oil. This difference between diabetic and normal rats appeared when rats were allowed to eat after oil ingestion as well as when they were fasted. Brief periods of food deprivation (2.5-4.5 hr) substantially increased plasma ketones and glycerol and decreased plasma triglycerides in both diabetic and normal rats. The results indicate that diabetic rats decrease food intake more than normal rats after fat feeding because they oxidize more of the ingested fat.
研究了高脂喂养抑制糖尿病大鼠食欲亢进的机制。允许摄入少量（1.5毫升）玉米油的大鼠在摄入后6小时内食物摄入量减少。糖尿病大鼠的食物摄入量比正常大鼠减少得多。经胃内给予油时也得到了类似的结果。对血样的分析表明，摄入1.5毫升玉米油后，糖尿病大鼠血浆酮和甘油三酯的增加幅度大于正常大鼠，而血浆甘油的增加幅度小于正常大鼠。糖尿病大鼠和正常大鼠之间的这种差异在大鼠摄入油后进食以及禁食时均出现。短时间禁食（2.5 - 4.5小时）显著增加了糖尿病大鼠和正常大鼠的血浆酮和甘油，并降低了血浆甘油三酯。结果表明，高脂喂养后糖尿病大鼠比正常大鼠食物摄入量减少更多，因为它们氧化了更多摄入的脂肪。
