神经管缺陷的产前诊断。III. 甲胎蛋白检测的重新评估。
Prenatal diagnosis of neural tube defects. III. A reevaluation of the alpha-fetoprotein assay.
作者信息
Kimball M E, Milunsky A, Alpert E
出版信息
Obstet Gynecol. 1977 May;49(5):532-6.
PMID:66652
Abstract
Alpha-fetoprotein was measured in 2209 amniotic fluid samples under improved assay conditions. All cases of open neural tube defects had elevated values greater than 5 SD above the mean. The false positive rate based on the 3 SD cutoff is estimated at less than 9.15%. Alpha-fetoprotein assays are recommended for all patients undergoing second trimester amniocentesis, optimally between 14 and 16 weeks' gestation.
摘要
在改良的检测条件下，对2209份羊水样本进行了甲胎蛋白检测。所有开放性神经管缺陷病例的值均高于平均值5个标准差。基于3个标准差临界值的假阳性率估计低于9.15%。建议对所有在孕中期进行羊膜穿刺术的患者进行甲胎蛋白检测，最佳检测孕周为妊娠14至16周。
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