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[胚胎及新生大鼠肝脏中的甲胎蛋白]

[Alpha-fetoprotein in the liver of embryonic and newborn rats].

作者信息

Shipova L Ia, Gusev A I

出版信息

Ontogenez. 1976;7(4):392-6.

PMID:66653
Abstract

The localization of alpha-fetoprotein in the liver of embryos and newborn Wistar rats was determined by the method of fluorescent antibodies. This protein was found in the cytoplasm of some hepatocytes, endothelium of blood vessels and erythroid blood cells of embryos and new born rats. It was never found in the blood-forming and Kupffer cells of the liver, as well as in the epithelium of bile ducts. The hepatocytes containing this protein were located in the liver lobes near the central veins. Their number and the intensity of fluorescence decreased with the age of animals.

摘要

采用荧光抗体法测定了胚胎期和新生Wistar大鼠肝脏中甲胎蛋白的定位。在胚胎期和新生大鼠的一些肝细胞、血管内皮及红细胞中发现了这种蛋白质。在肝脏的造血细胞、枯否细胞以及胆管上皮中从未发现过这种蛋白质。含有这种蛋白质的肝细胞位于中央静脉附近的肝叶中。随着动物年龄的增长,它们的数量和荧光强度会下降。

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