Ritchie A W, Chisholm G D
Semin Oncol. 1983 Dec;10(4):390-400.
In summary, some evidence indicating an increase in incidence of renal parenchymal malignancy has been presented. The nature of renal adenoma and its relationship to renal carcinoma remain uncertain, but it is possible that improved computerized tomography will allow in vivo identification of these lesions and initiate a long-term study to provide some clear data on their natural history. The heterogeneity of clinical presentation of this disease has been reviewed and the paraneoplastic syndromes and their importance summarized. Careful clinical and postmortem studies of disease spread, especially lymphatic spread, have been shown to provide useful information to the debate on the role of lymphadenectomy. Many of the unusual aspects of the natural history have been interpreted in terms of the hosts immune response and some data on the complexity and specificity of the host tumor interaction presented. In conclusion, an understanding of the natural history of renal carcinoma forms an important background on which to base clinical management and identifies areas worthy of further investigation in this curious tumor.
总之，已呈现出一些表明肾实质恶性肿瘤发病率增加的证据。肾腺瘤的性质及其与肾癌的关系仍不明确，但改进后的计算机断层扫描有可能实现对这些病变的体内识别，并启动一项长期研究，以提供有关其自然史的一些明确数据。本文回顾了该疾病临床表现的异质性，并总结了副肿瘤综合征及其重要性。对疾病扩散，尤其是淋巴扩散进行仔细的临床和尸检研究，已证明可为关于淋巴结切除术作用的辩论提供有用信息。自然史的许多不寻常方面已根据宿主的免疫反应进行了解释，并呈现了一些关于宿主与肿瘤相互作用的复杂性和特异性的数据。总之，了解肾癌的自然史构成了临床管理的重要背景，并确定了在这种奇特肿瘤中值得进一步研究的领域。
