Yonemoto J, Satoh H, Himeno S, Suzuki T
Teratology. 1983 Dec;28(3):333-40. doi: 10.1002/tera.1420280305.
Toxic effects of sodium selenite (SS) on dams and/or conceptuses and modification of the effects by vitamin E (VE) or reduced glutathione (GSH) were investigated in pregnant mice during late gestation. Dose-dependent fetocidal effects and fetal growth retardation were observed in mothers injected SC with SS on day 12 but not on day 16 of gestation. On day 12, abortion occurred only at a dose level of 58.8 mumol/kg SS, whereas on day 16 it occurred at two dose levels: 27.2 and 40.0 mumol/kg SS. Pregnant mice were treated with or without VE (50 mg/kg, SC, daily from day 7 to day 11) and injected with a single dose of SS (46.2 mumol/kg, SC) on day 12. VE prevented abortion and maternal death, but none of the other effects such as fetal loss, fetal growth retardation, and decrease in body weight gain of the dams. Pretreatment with GSH (0, 2, or 5 mM/kg, SC) 20 min before SS injection on day 12 exacerbated maternal death, abortion, and decrease in body weight gain of the dams. No effect were observed in the number of live offspring, and in body weight of offspring.
在妊娠晚期的怀孕小鼠中，研究了亚硒酸钠（SS）对母鼠和/或胚胎的毒性作用以及维生素E（VE）或还原型谷胱甘肽（GSH）对这些作用的影响。在妊娠第12天皮下注射SS的母鼠中观察到剂量依赖性的杀胚胎作用和胎儿生长迟缓，但在妊娠第16天未观察到。在第12天，仅在58.8 μmol/kg SS的剂量水平出现流产，而在第16天，在27.2和40.0 μmol/kg SS这两个剂量水平出现流产。怀孕小鼠在第7天至第11天每天皮下注射或不注射VE（50 mg/kg），并在第12天皮下注射单剂量的SS（46.2 μmol/kg）。VE可防止流产和母鼠死亡，但对其他影响如胚胎丢失、胎儿生长迟缓和母鼠体重增加减少均无作用。在第12天注射SS前20分钟用GSH（0、2或5 mM/kg，皮下注射）预处理会加重母鼠死亡、流产和母鼠体重增加减少。在存活后代数量和后代体重方面未观察到影响。
