Anger K, Möller T, Zeimantz E
Strahlentherapie. 1983 Dec;159(12):745-50.
In a retrospective study 1704 whole-body bone scans of 807 female and 7 male patients with breast cancer performed from 1974 to 1981 were reevaluated considering the incidence of bone metastases in staging and follow-up, the response of metastatic uptake to treatment as well as sensitivity and specificity of the diagnostic procedure. The yield of positive bone scans in staging was 23.7% at all and depended on T stage with a comparably high incidence of 8.8% in stage T1 and T2. Subsequently within 6 years follow-up further 26% were developing bone metastases. The long time response of known metastases to treatment was ambient, 65% of the scans found without some essential change. The incidence of bone metastases combined with a calculated sensitivity of 93% and specificity of 91% is justifying the use of bone scans in every stage and every phase of assessing breast cancer.
在一项回顾性研究中,对1974年至1981年间807例女性和7例男性乳腺癌患者的1704次全身骨扫描进行了重新评估,考虑了骨转移在分期和随访中的发生率、转移性摄取对治疗的反应以及诊断程序的敏感性和特异性。分期时骨扫描阳性率总体为23.7%,并取决于T分期,T1和T2期的发生率相对较高,为8.8%。随后在6年的随访中,又有26%的患者发生骨转移。已知转移灶对治疗的长期反应不明显,65%的扫描结果未发现有任何实质性变化。骨转移的发生率以及计算得出的93%的敏感性和91%的特异性证明了在评估乳腺癌的每个阶段和时期使用骨扫描是合理的。