The medical treatment of male infertility.

Mesterolone, HCG and PMS, clomiphene and various other drugs were administered to 236 subfertile patients with disturbed spermatogenesis. Most of the patients received mesterolone. The effects of the various therapeutic regimes are discussed. Improvement of the sperm count and spermatozoal motility was more frequent after mesterolone treatment than after HCG and PMS or after clomiphene. 14 wives of patients in the mesterolone group became pregnant and gave birth to normal children. There were two pregnancies in the gonadotropin group and 3 in the clomiphene group. Specific treatment of the few patients with varicocele or epididymitis led to improved findings in the spermiogram.