胍乙啶、溴苄铵和丁卡因对兔回肠交感神经刺激频率-反应关系的影响
Modification of sympathetic nerve stimulation frequency-response relationship in rabbit ileum by guanethidine, bretylium and tetracaine.
作者信息
Kihara M, Kubo T, Misu Y
出版信息
Arch Int Pharmacodyn Ther. 1983 Dec;266(2):180-5.
Effects of low concentrations of guanethidine, bretylium and tetracaine were comparatively studied with regard to inhibitory responses of rabbit ileum to periarterial nerve stimulation at 5, 10 and 20 Hz. Guanethidine 2 X 10(-7) to 10(-6) M and bretylium 3 X 10(-6) to 3 X 10(-5) M dose-dependently and preferentially reduced responses to lower frequencies, whereas tetracaine 10(-5) to 3 X 10(-5) M reduced responses, in a dose- and frequency-dependent manner. In conclusion, the mode of adrenergic neuron blocking action of guanethidine and bretylium differs from that of local anesthetics.
就家兔回肠对5、10和20赫兹动脉周围神经刺激的抑制反应而言，对低浓度胍乙啶、溴苄铵和丁卡因的作用进行了比较研究。2×10⁻⁷至10⁻⁶M的胍乙啶和3×10⁻⁶至3×10⁻⁵M的溴苄铵剂量依赖性地且优先降低对较低频率的反应，而10⁻⁵至3×10⁻⁵M的丁卡因则以剂量和频率依赖性方式降低反应。总之，胍乙啶和溴苄铵的肾上腺素能神经元阻断作用方式不同于局部麻醉药。
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