Galvez Alvarez J, Garcia Segui C, Garcia Domenech R, Moreno Frigols J
Int J Appl Radiat Isot. 1983 Dec;34(12):1647-9. doi: 10.1016/0020-708x(83)90018-2.
Some physico-chemical characteristics of the colloidal radiopharmaceutical [99mTc]Ca-phytate related to optimal preparation conditions have been studied. It is demonstrated that the Ca2+-phytate stoichiometry is 6:1. Two different Ca-phytate colloids seem to be formed, mainly depending on the Ca2+:phytate molar ratio--one of low mycelar size for a 1:1 Ca2+:phytate molar ratio (cmc = 5.10(-5) M), and another one, with a higher mycelar size for a 6:1 molar ratio (cmc = 8.10(-5) M). This last one it probably better for providing a good quality splenic uptake.
已对与最佳制备条件相关的胶体放射性药物[99mTc]植酸钙的一些物理化学特性进行了研究。结果表明，钙与植酸的化学计量比为6:1。似乎形成了两种不同的植酸钙胶体，主要取决于钙与植酸的摩尔比——一种是钙与植酸摩尔比为1:1时菌丝体尺寸较小（临界胶束浓度 = 5×10⁻⁵ M），另一种是摩尔比为6:1时菌丝体尺寸较大（临界胶束浓度 = 8×10⁻⁵ M）。后一种可能更有利于实现良好的脾脏摄取质量。
