[Long-term treatment of arterial hypertension with a new combined preparation obsilazin].

Thirty-three patients with essential hypertension and two with symptomatic arterial hypertension (Stage I-III) were treated for about two years with the drug obsilazin containing 50 mg propranolol and 50 mg dihydralazin per tablet (the maximum average dose of each drug was 174 mg/day). In 18 patients (51.4%), the arterial pressure returned to normal; in 16 (45.7%) it dropped by more than 10% and one patient showed no response to the treatment. The decrease in systolic and diastolic pressure averaged 20%. The hypotensive effect of obsilazin lasted for several years, attended by no paradoxical reactions on the part of arterial pressure. In individual treatment-refractory cases, the hypotensive effect of obsilazin was strengthened by adding disostate into the treatment modality studied.