Attramadal A, Weddington S C, Naess O, Djoseland O, Hansson V
Prog Clin Biol Res. 1976;6:189-203.
A brief description of physicochemical properties of the androgen receptors in the various target tissues is given. It is suggested that androgen receptors in all organs and species are very similar if not identical. It is also suggested that apparent differences in steroid binding are not due to differences in steroid specificity of receptors, but rather due to organ specific differences in target tissue metabolism. A short discussion of our studies on androgen receptors in the prostate, epididymis and testis of human being is also included. The properties of these receptors are similar, if not identical to those described in rats, and we have not been able to demonstrate differences in androgen receptors of non-neoplastic and neoplastic tissue. From studies on testosterone metabolism it is demonstrated that human prostate is metabolizing testosterone to DHT much faster than the seminal vesicles. Furthermore, there is a drastic reduction in DHT formation in tissue from prostatic cancer compared to normal and hyperplastic prostatic tissue.
文中给出了各种靶组织中雄激素受体的理化性质的简要描述。研究表明，所有器官和物种中的雄激素受体即便不完全相同也极为相似。还表明，类固醇结合的明显差异并非由于受体的类固醇特异性不同，而是由于靶组织代谢中的器官特异性差异。文中还简要讨论了我们对人类前列腺、附睾和睾丸中雄激素受体的研究。这些受体的性质即便与大鼠中描述的不完全相同也很相似，而且我们未能证明非肿瘤组织和肿瘤组织的雄激素受体存在差异。从睾酮代谢研究中可以看出，人类前列腺将睾酮代谢为双氢睾酮的速度比精囊快得多。此外，与正常和增生性前列腺组织相比，前列腺癌组织中的双氢睾酮生成大幅减少。
