Gerin J L, Tennant B C, Ponzetto A, Purcell R H, Tyeryar F J
Prog Clin Biol Res. 1983;143:23-8.
As a model of virus-induced disease, the WHV/woodchuck system is at an early stage of development; yet, much progress has been made and there now exists considerable evidence that WHV causes serious liver disease with major parallels to HBV infection of man. The relatively short interval (4-5 yrs) from infection to end-stage disease in this model provides unique opportunities for definition of the natural history of HBV disease and the evaluation of various intervention strategies (e.g., vaccine prophylaxis and anti-viral therapy). Such studies are currently in progress in a number of laboratories.
