Andersen B N, Petersen B, Borch K, Rehfeld J F
Scand J Gastroenterol. 1983 May;18(4):565-9. doi: 10.3109/00365528309181639.
The basal concentrations of sulfated and non-sulfated gastrins in serum were measured radioimmunochemically in healthy subjects and in normo- and hyper-gastrinemic diseases. The degree of sulfation in patients with duodenal and gastric ulcer, chronic pancreatitis, gallstone disease, and chronic renal failure were similar to that of healthy controls, in whom 37.7 +/- 1.9% (mean +/- SEM) of serum gastrins were sulfated. In eight patients with the Zollinger-Ellison syndrome 57 +/- 5.4% of the gastrins were sulfated (p less than 0.005, compared with controls). In patients with pernicious anemia (no. = 20) only 24.4 +/- 2.0% of the gastrins were sulfated (p less than 0.005, compared with controls). An inverse correlation (r = -0.63, p less than 0.01) was found between the degree of sulfation and the total gastrin concentration in pernicious anemia but not in gastrinoma patients. The results indicate that diseases with increased synthesis of gastrin are accompanied by an abnormal degree of sulfation.
采用放射免疫化学方法测定了健康受试者以及正常和高胃泌素血症疾病患者血清中硫酸化和非硫酸化胃泌素的基础浓度。十二指肠溃疡、胃溃疡、慢性胰腺炎、胆结石病和慢性肾衰竭患者的硫酸化程度与健康对照者相似，健康对照者血清胃泌素的硫酸化率为37.7±1.9%（平均值±标准误）。8例佐林格-埃利森综合征患者胃泌素的硫酸化率为57±5.4%（与对照组相比，p<0.005）。在20例恶性贫血患者中，只有24.4±2.0%的胃泌素发生了硫酸化（与对照组相比，p<0.005）。在恶性贫血患者中，硫酸化程度与总胃泌素浓度呈负相关（r = -0.63，p<0.01），但在胃泌素瘤患者中未发现这种相关性。结果表明，胃泌素合成增加的疾病伴随着异常的硫酸化程度。
