Federici A, Sorrentino G, Nocera L, Ruccia D, Di Benedetta C
Boll Soc Ital Biol Sper. 1983 Dec 30;59(12):1942-7.
It was reported by the literature that a train stimulation, simultaneously delivered on the two vagi, resulted in a decrement of the negative chronotropic effect, when it was compared to the sum of the effects obtained by the stimulation of the two nerves, separately. Our data indicate that the size of the chronotropic effect obtained by the simultaneous application on the two vagi of a single supraliminar stimulus, randomly applied within the P-P cycle, in rabbits, can be equal, higher or lower than the sum of the same stimulation separately delivered to the two nerves. The results could depend upon the different amount of acetylcholine released during stimulation. The hypothesis is put forward that different patterns of the neuro-cardiac junction regulation might be activated according to the quantity of released neuromediator.
据文献报道，与分别刺激两条迷走神经所获得的效应之和相比，同时刺激两条迷走神经会导致负性变时效应减弱。我们的数据表明，在兔的P-P周期内随机施加单个阈上刺激同时作用于两条迷走神经所获得的变时效应大小，可能等于、高于或低于分别刺激两条神经时相同刺激的效应之和。结果可能取决于刺激过程中释放的乙酰胆碱量不同。据此提出假说，即根据释放的神经介质数量，可能会激活神经-心脏连接调节的不同模式。
