Takayanagi N, Tozuka T, Toda N
Nihon Yakurigaku Zasshi. 1983 Nov;82(5):383-93.
Subcutaneous injections of elcatonin, a synthetic analogue of eel calcitonin, lowered the blood pressure in DOCA/saline-hypertensive and spontaneously hypertensive rats (SHR), but not in normotensive Wistar rats. The hypotensive effect was more prominent in the DOCA hypertensive rats. Daily injections of elcatonin (10-30 U/kg/day for 21 days) resulted in maximum hypotension on the 4th day in DOCA hypertensive rats and on the 14th day in SHR, and the reduced level of blood pressure was maintained. After the cessation of elcatonin injections, the pressure started to elevate gradually towards the control level. In normotensive rats, elcatonin did not significantly alter the blood pressure for 6 weeks. Daily injections of elcatonin significantly prevented the development of DOCA-induced hypertension and spontaneously-occurring hypertension. Elcatonin-induced hypotension did not differ in the control and parathyroidectomized DOCA hypertensive rats. Elcatonin did not alter the pressor response to noradrenaline, vasopressin and angiotensin II nor the depressor response to isoproterenol, acetylcholine and histamine in DOCA hypertensive rats. It is concluded that the antihypertensive effect of elcatonin is not associated with the release of parathyroid hormone nor with the blockade of alpha, beta, angiotensin II and vasopressin receptors.
皮下注射鳗鱼降钙素的合成类似物依降钙素，可使去氧皮质酮/盐水诱导的高血压大鼠和自发性高血压大鼠（SHR）的血压降低，但对正常血压的Wistar大鼠无效。在去氧皮质酮高血压大鼠中，降压作用更为显著。每天注射依降钙素（10 - 30 U/kg/天，共21天），在去氧皮质酮高血压大鼠中第4天血压降至最低，在SHR中第14天血压降至最低，且血压降低水平得以维持。停止注射依降钙素后，血压开始逐渐回升至对照水平。在正常血压大鼠中，依降钙素在6周内未显著改变血压。每天注射依降钙素可显著预防去氧皮质酮诱导的高血压和自发性高血压的发展。依降钙素诱导的低血压在对照和甲状旁腺切除的去氧皮质酮高血压大鼠中无差异。依降钙素不改变去氧皮质酮高血压大鼠对去甲肾上腺素、血管加压素和血管紧张素II的升压反应，也不改变对异丙肾上腺素、乙酰胆碱和组胺的降压反应。结论是，依降钙素的降压作用与甲状旁腺激素的释放无关，也与α、β、血管紧张素II和血管加压素受体的阻断无关。
