Molina E, Gregori G, De Angelis G L, Ghinelli C, Scuto S, Banchini G
Int J Tissue React. 1983;5(4):407-10.
Six cases of duodenal ulcer were studied in male children (mean age 8.8 yrs., range 6-12 yrs., mean weight 29.8 kg). All were submitted to X-ray examination and/or digestive endoscopy. Ten healthy children, matched by weight, age and sex were chosen as controls. All children underwent a standardized protein meal to evaluate serum gastrin and pepsinogen I response and the pentagastrin test for acid secretion. The serum gastrin level was found to be similar in the two groups (normal children and duodenal ulcer) both in the fasting state and after food stimulation, whereas the basal and after-meal serum pepsinogen I values were statistically higher in the duodenal ulcer group (p less than 0.01). The pentagastrin test showed a basal, maximal and peak acid output significantly lower in controls than in the subjects with primary duodenal ulcer. The results confirm that elevated gastric acid response is already present in duodenal ulcer of childhood and seems to be its cause rather than its consequence. Our finding of an already elevated pepsinogen I level, coupled with the already reported family histories of the disease, further support an inherited basis for duodenal ulcer in childhood.
对6例男性儿童十二指肠溃疡进行了研究（平均年龄8.8岁，范围6 - 12岁，平均体重29.8千克）。所有患儿均接受了X线检查和/或消化内镜检查。选择10名年龄、体重和性别相匹配的健康儿童作为对照。所有儿童均接受标准化蛋白质餐，以评估血清胃泌素和胃蛋白酶原I反应以及用于胃酸分泌的五肽胃泌素试验。结果发现，在空腹状态和食物刺激后，两组（正常儿童和十二指肠溃疡患儿）的血清胃泌素水平相似，而十二指肠溃疡组的基础和餐后血清胃蛋白酶原I值在统计学上显著更高（p < 0.01）。五肽胃泌素试验显示，对照组的基础胃酸分泌量、最大胃酸分泌量和高峰胃酸分泌量显著低于原发性十二指肠溃疡患儿。这些结果证实，儿童十二指肠溃疡中已经存在胃酸反应升高，这似乎是其病因而非结果。我们发现胃蛋白酶原I水平已经升高，再加上已经报道的该病家族史，进一步支持了儿童十二指肠溃疡的遗传基础。
