Gedde-Dahl D
Scand J Gastroenterol. 1975;10(2):187-91.
A test meal was given to 9 male controls and 9 male patients with duodenal ulcer. The serum gastrin concentrations were determined by radioimmunoassay, and gastric secretion of acid was determined before and after stimulation with 6 mug pentagastrin per kg body weight given subcutaneously. The pattern of gastrin response was found to be biphasic, with an early maximum of the first peak in the patients versus a monophasic response with a maximum in the second hour in the controls. Fasting serum gastrin levels were positively correlated to the basal acid outputs (BAO) in the patients but not in the controls. The mean quotient BAO/Fasting serum gastrin concentration was highest in the patient group, but the quotient of "maximal" acid output (MAO)-BAO/"integrated gastrin response" was equal in the two groups.
给9名男性对照者和9名十二指肠溃疡男性患者进行了一次试餐。通过放射免疫分析法测定血清胃泌素浓度，并在皮下注射每千克体重6微克五肽胃泌素刺激前后测定胃酸分泌。发现胃泌素反应模式呈双相性，患者的第一个峰值在早期达到最大值，而对照者的反应呈单相性，在第二小时达到最大值。患者的空腹血清胃泌素水平与基础酸排出量（BAO）呈正相关，而对照者则不然。患者组的平均BAO/空腹血清胃泌素浓度比值最高，但两组的“最大”酸排出量（MAO）-BAO/“整合胃泌素反应”比值相等。
